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KMID : 0363220190570040209
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Korean Journal of Dermatology
2019 Volume.57 No. 4 p.209 ~ p.212
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Three Cases of Recurrent Cheilitis Granulomatosa Treated with Variable Combination Therapy
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Ham Seung-Pil
Park Hee-Jae
Woo Cheong-Ha
Choi Mi-Ra
Park Hai-Jin
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Abstract
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Cheilitis granulomatosa (CG) is a subset of orofacial granulomatosis (OFG) and considered to be a monosymptomatic form of Melkersson-Rosenthal syndrome (MRS), which is characterized by the triad of chronic lip swelling, facial paralysis, and fissured tongue. The labial swelling is thought to be associated with an orofacial swelling, which affects the chin, cheeks, and oral mucosa. Histologically, it is distinguished by noncaseating granulomas consisting of lymphohistiocytes and giant cells. Although systemic steroids with or without intralesional triamcinolone injections are the mainstay of treatment, and various agents have been proposed for this rare disease, no successful treatment modality has been reported in the literature yet. Herein, we present our experience with three different CG cases, which showed a varied level of positive response to the combination therapy. (Korean J Dermatol 2019;57(4):209∼212)
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KEYWORD
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Cheilitis granulomatosa, Melkersson-Rosenthal syndrome, Orofacial granulomatosis
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